RENT2/UPF2 anticorps (N-Term)

N° du produit ABIN2779085

Détail du produit anti-RENT2/UPF2 anticorps

Antigène: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Cheval, Boeuf (Vache), Porc, Chien, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RENT2/UPF2 est non-conjugé

Application: Western Blotting (WB)

Séquence: KAPEDKKKRL EDDKRKKEDK ERKKKDEEKV KAEEESKKKE EEEKKKHQEE

Homologie: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rat: 86%, Yeast: 86%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against UPF2. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human UPF2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1272 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RENT2/UPF2

Antigène: RENT2/UPF2 (UPF2) (UPF2 Regulator of Nonsense Transcripts 2 (UPF2))

Autre désignation: UPF2 (UPF2 Produits)

Synonymes: anticorps HUPF2, anticorps RENT2, anticorps smg-3, anticorps UPF2, regulator of nonsense mediated mRNA decay, anticorps UPF2 regulator of nonsense transcripts homolog (yeast), anticorps UPF2, anticorps Upf2, anticorps upf2

Sujet: This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene, both variants encode the same protein.
Alias Symbols: DKFZp434D222, HUPF2, KIAA1408, MGC138834, MGC138835, RENT2, smg-3
Protein Interaction Partner: PUF60, UBC, UPF1, LGR4, MIF, LDHA, KRT18, ITGB1, HMGA1, ZBTB48, HBZ, ENO1, E4F1, CYBA, CALR, BLM, ATP1B3, ART4, DCP1B, DCP2, COMTD1, EXOSC6, GADD45GIP1, ZGPAT, MAP1LC3B, ZNF408, CENPU, WNK1, RSRC2, MRPL40, ZNF44, EXOSC1, MTERF3, GLTSCR2, NOB1, RRP7A, SERB
Protein Size: 1272

Poids moléculaire: 148 kDa

ID gène: 26019

NCBI Accession: NM_015542, NP_056357

UniProt: Q9HAU5