FKBP4 anticorps (C-Term)

N° du produit ABIN2779294

Cet anticorps Lapin Polyclonal détecte spécifiquement FKBP4 dans WB et IHC. Il présente une réactivité envers Humain et Porc.

Aperçu rapide pour FKBP4 anticorps (C-Term) (ABIN2779294)

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FKBP4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-FKBP4 anticorps

Épitope: C-Term

Séquence: ANMFERLAEE ENKAKAEASS GDHPTDTEMK EEQKSNTAGS QSQVETEA

Homologie: Human: 100%, Pig: 75%

Attributs du produit: This is a rabbit polyclonal antibody against FKBP4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human FKBP4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 459 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur FKBP4

Antigène: FKBP4 (FK506 Binding Protein 4, 59kDa (FKBP4))

Autre désignation: FKBP4

Sujet: FKBP4 is a component of unactivated mammalian steroid receptor complexes that sediment at 8-10 S. It may have a rotamase activity. FKBP4 may play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FKBP52, FKBP59, HBI, Hsp56, PPIase, p52, FKBP51
Protein Interaction Partner: HSP90AB1, HSP90AA1, RPS10-NUDT3, CDC37L1, LSM7, CACYBP, CHORDC1, GLMN, CDC37, SUGT1, USP19, PTGES3, AHSA1, UBC, MDM2, MGEA5, TPM3, MCM4, MCM3, SQSTM1, Nr3c1, S100A6, S100A2, S100A1, gag-pol, VCAM1, TAF9, SNCA, SARDH, UBD, PGR, NR3C2, AR, CDK2, SIRT7, SH3B
Protein Size: 459

Poids moléculaire: 52 kDa

ID gène: 2288

NCBI Accession: NM_002014, NP_002005

UniProt: P30416

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway