RAD17 anticorps (N-Term)

N° du produit ABIN2779342

Détail du produit anti-RAD17 anticorps

Antigène: RAD17

Épitope: N-Term

Reactivité: Humain, Rat, Chien, Boeuf (Vache), Porc, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD17 est non-conjugé

Application: Western Blotting (WB)

Séquence: MNQVTDWVDP SFDDFLECSG VSTITATSLG VNNSSHRRKN GPSTLESSRF

Homologie: Cow: 89%, Dog: 100%, Horse: 92%, Human: 100%, Pig: 100%, Rabbit: 100%, Rat: 89%

Attributs du produit: This is a rabbit polyclonal antibody against RAD17. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RAD17

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 670 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RAD17

Antigène: RAD17

Autre désignation: RAD17 (RAD17 Produits)

Synonymes: anticorps zgc:91969, anticorps RAD17, anticorps K2A18.21, anticorps K2A18_21, anticorps RADIATION SENSITIVE 17, anticorps CCYC, anticorps HRAD17, anticorps R24L, anticorps RAD17SP, anticorps RAD24, anticorps 9430035O09Rik, anticorps MmRad24, anticorps RAD17 checkpoint clamp loader component, anticorps Rad17p, anticorps RADIATION SENSITIVE 17, anticorps RAD17, anticorps rad17, anticorps ATRAD17, anticorps Rad17

Sujet: RAD17 is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation.
Alias Symbols: CCYC, FLJ41520, HRAD17, R24L, RAD17SP, RAD24
Protein Interaction Partner: USP20, UBC, PRMT6, CBX7, CBX6, RAD9A, CDH1, ATR, RFC1, H2AFX, FOXO3, ATM, CLSPN, ALK, RAD9B, POLE, HUS1, RAD1, NHP2L1, MCM7, RFC4, RFC5, RFC3, RFC2, POLE4, POLE3, POLE2, PRKDC,
Protein Size: 670

Poids moléculaire: 76 kDa

ID gène: 5884

NCBI Accession: NM_002873, NP_002864