LMX1A anticorps (Middle Region)

N° du produit ABIN2779408

Cet anticorps anti-LMX1A est un anticorps Lapin Polyclonal détectant LMX1A dans WB et IHC. Adapté pour Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye et Lapin.

Aperçu rapide pour LMX1A anticorps (Middle Region) (ABIN2779408)

Antigène: LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))

Reactivité: Humain, Souris, Rat, Chien, Cheval, Boeuf (Vache), Cobaye, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp LMX1A est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-LMX1A anticorps

Épitope: Middle Region

Séquence: QNQRAKMKKL ARRQQQQQQD QQNTQRLSSA QTNGGGSAGM EGIMNPYTAL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against LMX1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human LMX1A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 382 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur LMX1A

Antigène: LMX1A (LIM Homeobox Transcription Factor 1, alpha (LMX1A))

Autre désignation: LMX1A

Sujet: Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin. Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS, MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM]. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-199 AL160058.8 14249-14447 c 200-2447 AK127724.1 362-2609 2448-3382 AL390730.12 9415-10349 c
Alias Symbols: LMX-1, LMX1, LMX1.1, MGC87616
Protein Interaction Partner: LDB1, BMPR2, ISL1, LHX3, LMX1A, TCF3,
Protein Size: 382

Poids moléculaire: 43 kDa

ID gène: 4009

NCBI Accession: NM_177398, NP_796372

UniProt: Q8TE12

Pathways: Dopaminergic Neurogenesis