SMAD7 anticorps (N-Term)

N° du produit ABIN2779418

Cet anticorps anti-SMAD7 est un anticorps Lapin Polyclonal détectant SMAD7 dans WB. Adapté pour Humain, Souris, Rat, Porc, Boeuf (Vache), Chien et Lapin. Ce Primary Antibody a été cité dans 1 publication.

Aperçu rapide pour SMAD7 anticorps (N-Term) (ABIN2779418)

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Reactivité: Humain, Souris, Rat, Porc, Boeuf (Vache), Chien, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SMAD7 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-SMAD7 anticorps

Épitope: N-Term

Séquence: LVRRLWRSRA PGGEDEEEGA GGGGGGGELR GEGATDSRAH GAGGGGPGRA

Homologie: Cow: 93%, Dog: 93%, Human: 100%, Mouse: 92%, Pig: 93%, Rabbit: 93%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against SMAD7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SMAD7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 426 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SMAD7 (ABIN2779418)

Briones-Orta, Sosa-Garrocho, Moreno-Alvarez, Fonseca-Sánchez, Macías-Silva: "SnoN co-repressor binds and represses smad7 gene promoter." dans: Biochemical and biophysical research communications, Vol. 341, Issue 3, pp. 889-94, (2006) (PubMed).

Détails sur SMAD7

Antigène: SMAD7 (SMAD, Mothers Against DPP Homolog 7 (SMAD7))

Autre désignation: SMAD7

Sujet: Smad7 acts to functionally inactivate RB and de-repress E2F without blocking the activation of TbetaRI and the nuclear translocation of Smad2/3, allowing TGF-beta1 to exert effects in a cancer cell that is resistant to TGF-beta1-mediated growth inhibition.
Alias Symbols: FLJ16482, MADH7, MADH8, CRCS3
Protein Interaction Partner: HDAC3, HDAC2, USP11, SMURF2, SMURF1, SKP2, MYC, Melk, HCVgp1, RNF111, KDM2A, SOX13, PIAS1, SOX7, UBE2O, MKL2, ASH1L, PIAS4, CXXC5, ZNF107, ZBTB11, HEYL, TTF2, UBC, TTF1, SOX5, MYOD1, XRCC6, CTNNB1, MAPK14, BAMBI, PPP1R15A, NEDD4L, STAMBP, YAP1, AXIN1, TP5
Protein Size: 426

Poids moléculaire: 46 kDa

ID gène: 4092

NCBI Accession: NM_005904, NP_005895

UniProt: O15105

Pathways: Interferon-gamma Pathway, Cell-Cell Junction Organization