ESR2 anticorps (Middle Region)

N° du produit ABIN2779528

Cet anticorps anti-ESR2 est un anticorps Lapin Polyclonal détectant ESR2 dans WB. Adapté pour Humain, Souris, Rat, Mouton, Porc, Cheval, Chien, Boeuf (Vache), Lapin, Cobaye et Chévre.

Aperçu rapide pour ESR2 anticorps (Middle Region) (ABIN2779528)

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivité: Humain, Souris, Rat, Mouton, Porc, Cheval, Chien, Boeuf (Vache), Lapin, Cobaye, Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ESR2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ESR2 anticorps

Épitope: Middle Region

Séquence: EYLCVKAMIL LNSSMYPLVT ATQDADSSRK LAHLLNAVTD ALVWVIAKSG

Homologie: Cow: 86%, Dog: 86%, Goat: 86%, Guinea Pig: 79%, Horse: 79%, Human: 100%, Mouse: 86%, Pig: 86%, Rabbit: 86%, Rat: 86%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against ESR2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ESR2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 530 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ESR2

Antigène: ESR2 (Estrogen Receptor 2 (ESR2))

Autre désignation: ESR2

Sujet: ESR2 is a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. It contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Alias Symbols: ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2
Protein Interaction Partner: PLSCR1, MEOX2, NOTCH2NL, RFX6, MMS19, BCAS2, NCOA1, RPS18, MRPS15, MRPS22, ZC3HAV1, PTCD3, EXOSC4, MRPS2, MED4, MRPS27, MRPS31, MED17, TRIM24, NRIP1, NCOA3, STAU1, SP1, PABPC5, MYLK2, RPS11, RPS4X, RPLP0, RPL36AL, PPP5C, HSPA8, ESR2, ESR1, ACTB, SRA1, ARI
Protein Size: 530

Poids moléculaire: 59 kDa

ID gène: 2100

NCBI Accession: NM_001437, NP_001428

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling