RUVBL1 anticorps (N-Term)

N° du produit ABIN2779583

Cet anticorps anti-RUVBL1 Polyclonal Lapin (ABIN2779583) détecte spécifiquement RUVBL1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio) et Chévre.

Aperçu rapide pour RUVBL1 anticorps (N-Term) (ABIN2779583)

Antigène: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio), Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RUVBL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RUVBL1 anticorps

Épitope: N-Term

Fonction: RUVBL1 Antibody - N-terminal region

Séquence: KIEEVKSTTK TQRIASHSHV KGLGLDESGL AKQAASGLVG QENAREACGV

Homologie: Cow: 100%, Dog: 100%, Goat: 77%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RUVBL1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RUVBL1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP32349-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur RUVBL1

Antigène: RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))

Autre désignation: RUVBL1

Sujet:

Background Information: RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.

Gene Name: RuvB-like 1 (E. coli)

Alternative Symbols: RVB1, TIH1, ECP54, TIP49, ECP-54, INO80H, NMP238, PONTIN, TIP49A, NMP 238, Pontin52

Protein Name: RuvB-like 1

Poids moléculaire: 50kDa

ID gène: 8607

NCBI Accession: NP_003698

UniProt: Q9Y265

Pathways: Telomere Maintenance