Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PITX2 anticorps (N-Term)

PITX2 Reactivité: Humain, Souris, Cheval, Cobaye WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2779637
  • Antigène Voir toutes PITX2 Anticorps
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Épitope
    • 10
    • 9
    • 9
    • 8
    • 6
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 59
    • 6
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Cheval, Cobaye
    Hôte
    • 53
    • 5
    • 1
    Lapin
    Clonalité
    • 56
    • 3
    Polyclonal
    Conjugué
    • 29
    • 6
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PITX2 est non-conjugé
    Application
    • 47
    • 38
    • 6
    • 5
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    METNCRKLVS ACVQLGVQPA AVECLFSKDS EIKKVEFTDS PESRKEAASS
    Homologie
    Guinea Pig: 92%, Horse: 100%, Human: 100%, Mouse: 93%
    Attributs du produit
    This is a rabbit polyclonal antibody against PITX2. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human PITX2
    Top Product
    Discover our top product PITX2 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 317 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Holmberg, Ingner, Johansson, Leander, Hjalt: "PITX2 gain-of-function induced defects in mouse forelimb development." dans: BMC developmental biology, Vol. 8, pp. 25, (2008) (PubMed).

  • Antigène
    PITX2 (Paired-Like Homeodomain 2 (PITX2))
    Autre désignation
    PITX2 (PITX2 Produits)
    Synonymes
    anticorps ARP1, anticorps Brx1, anticorps IDG2, anticorps IGDS, anticorps IGDS2, anticorps IHG2, anticorps IRID2, anticorps Otlx2, anticorps PTX2, anticorps RGS, anticorps RIEG, anticorps RIEG1, anticorps RS, anticorps 9430085M16Rik, anticorps Brx1a, anticorps Brx1b, anticorps Munc30, anticorps Pitx2a, anticorps Pitx2b, anticorps Pitx2c, anticorps Pitx2cbeta, anticorps Ptx2, anticorps Rieg, anticorps pitx2a, anticorps pitx2c, anticorps zgc:110508, anticorps XPtx2b, anticorps xPtx2, anticorps xpitx2, anticorps arp1, anticorps brx1, anticorps idg2, anticorps igds, anticorps igds2, anticorps ihg2, anticorps irid2, anticorps otlx2, anticorps pitx2-A, anticorps ptx2, anticorps rgs, anticorps rieg, anticorps rieg1, anticorps pitx-2, anticorps pitx2, anticorps paired like homeodomain 2, anticorps paired-like homeodomain transcription factor 2, anticorps paired-like homeodomain 2, anticorps paired like homeodomain 2 S homeolog, anticorps paired like homeodomain 2 L homeolog, anticorps PITX2, anticorps Pitx2, anticorps pitx2, anticorps pitx2.S, anticorps pitx2.L
    Sujet
    The PITX2 gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. Mutations in PITX2 are associated with Axenfeld-Rieger syndrome (ARS), iridogoniodysgenesis syndrome (IGDS), and sporadic cases of Peters anomaly. This protein is involved in the development of the eye, tooth and abdominal organs. It also acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
    Alias Symbols: ARP1, Brx1, IDG2, IGDS, IGDS2, IHG2, IRID2, MGC111022, MGC20144, Otlx2, PTX2, RGS, RIEG, RIEG1, RS
    Protein Interaction Partner: LEF1, Hoxa1, WDR5, SMAD3, HDAC1, CTNNB1, ZNHIT3, TRIM25, HERC5, PDLIM1, PITX2, PROP1, KAT5, Pou1f1, MSX2,
    Protein Size: 317
    Poids moléculaire
    35 kDa
    ID gène
    5308
    NCBI Accession
    NM_153426, NP_700475
    UniProt
    Q99697
    Pathways
    Retinoic Acid Receptor Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
Vous êtes ici:
Support technique