REST anticorps (Middle Region)

N° du produit ABIN2779670

Détail du produit anti-REST anticorps

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REST est non-conjugé

Application: Western Blotting (WB)

Séquence: PMLPPSAVEE REAVSKTALA SPPATMAANE SQEIDEDEGI HSHEGSDLSD

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 93%, Rabbit: 93%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against REST. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human REST

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1097 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-REST (ABIN2779670)

Mehta, Kim, Vemuganti: "Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated Chromatin-Modifying Proteins." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 35, Issue 50, pp. 16443-9, (2015) (PubMed).

Détails sur REST

Antigène: REST (RE1-Silencing Transcription Factor (REST))

Autre désignation: REST (REST Produits)

Synonymes: anticorps NRSF, anticorps XBR, anticorps 2610008J04Rik, anticorps AA407358, anticorps xbr, anticorps nrsf, anticorps rest, anticorps resta, anticorps REST, anticorps RE1 silencing transcription factor, anticorps RE1-silencing transcription factor, anticorps RE1-silencing transcription factor S homeolog, anticorps REST, anticorps Rest, anticorps rest.S, anticorps rest, anticorps LOC615792

Sujet: REST is a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis.This gene encodes a transcriptional repressor which represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells, and it is thought that this repressor may act as a master negative regular of neurogenesis. Alternatively spliced transcript variants have been described, however, their full length nature has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: NRSF, XBR
Protein Interaction Partner: BTRC, UBC, FBXW11, CSNK1E, NEDD8, EHMT2, EIF4A3, FBXW4, FBXW7, FBXW5, FBXW8, FBXW2, SIN3A, TERF2, GRIA2, SUB1, GTF2B, Tbp, SIN3B, HDAC1, RCOR1, SP1, SMARCE1, SMARCC2, SMARCA4, CDYL, HDAC5, HDAC4, HTT, NCOR1, KDM5C, RNF2, HDAC2, STMN2, GRM2, CTDSP1,
Protein Size: 1097

Poids moléculaire: 122 kDa

ID gène: 5978

NCBI Accession: NM_005612, NP_005603

UniProt: Q13127

Pathways: Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity