NCOA3 anticorps (Middle Region)

N° du produit ABIN2779677

Cet anticorps Lapin Polyclonal détecte spécifiquement NCOA3 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval et Porc.

Aperçu rapide pour NCOA3 anticorps (Middle Region) (ABIN2779677)

Antigène: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NCOA3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NCOA3 anticorps

Épitope: Middle Region

Séquence: DQNPVESSMC QSNSRDHLSD KESKESSVEG AENQRGPLES KGHKKLLQLL

Homologie: Cow: 77%, Dog: 90%, Horse: 92%, Human: 100%, Mouse: 83%, Pig: 92%, Rat: 92%

Attributs du produit: This is a rabbit polyclonal antibody against NCOA3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human NCOA3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1420 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NCOA3

Antigène: NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

Autre désignation: NCOA3

Sujet: NCOA3 is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.The protein encoded by this gene is a nuclear receptor coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activator functions. The encoded protein has histone acetyltransferase activity and recruits p300/CBP-associated factor and CREB binding protein as part of a multisubunit coactivation complex. This protein is initially found in the cytoplasm but is translocated into the nucleus upon phosphorylation. Two transcript variants encoding different isoforms have been found for this gene. In addition, a polymorphic repeat region is found in the C-terminus of the encoded protein.
Alias Symbols: ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, MGC141848, RAC3, SRC-1, SRC3, TNRC14, TNRC16, TRAM-1, pCIP, SRC-3, bHLHe42
Protein Interaction Partner: PSMB9, PPARG, CUL3, ARNT2, MMS19, FBXW7, SPOP, UBC, E2F1, PTEN, ESR2, ALB, NR1I2, THRB, CHUK, KANK2, ESR1, NR3C1, MYOCD, MKL1, MKL2, PSME3, UBE3A, TP53, RARA, MAPK1, PIN1, PGR, EP300, ELAVL1, MAPK14, CREBBP, CEBPD, CEBPA, TP53BP1, TFF1, PSMC5, PSMA3, PRKC
Protein Size: 1420

Poids moléculaire: 155 kDa

ID gène: 8202

NCBI Accession: NM_006534, NP_006525

UniProt: Q0VF45

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha