AIRE anticorps (Autoimmune Regulator) (N-Term)

Details for Product anti-AIRE Antibody No. ABIN2779776, Fournisseur: Connectez-vous pour afficher
Antigène
  • AIRE1
  • APECED
  • APS1
  • APSI
  • PGA1
  • autoimmune regulator
  • autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)
  • AaeL_AAEL013794
  • CpipJ_CPIJ001208
  • CpipJ_CPIJ001209
  • AIRE
  • Aire
Épitope
N-Term
37
18
17
15
10
10
6
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cheval, Humain, Porc, Rat (Rattus)
147
72
29
10
8
7
4
4
4
2
1
Hôte
Lapin
96
57
18
1
Clonalité
Polyclonal
Conjugué
Cet anticorp AIRE est non-conjugé
8
6
5
5
5
5
2
2
2
2
2
2
1
Application
Western Blotting (WB)
147
86
41
35
19
18
13
6
5
5
2
1
1
1
Options
Fournisseur
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N° du produit (Fournisseur)
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Immunogène The immunogen is a synthetic peptide directed towards the N terminal region of human AIRE
Séquence DFWRVLFKDY NLERYGRLQP ILDSFPKDVD LSQPRKGRKP PAVPKALVPP
Homologie Cow: 79%, Dog: 92%, Horse: 86%, Human: 100%, Pig: 93%, Rat: 79%
Attributs du produit This is a rabbit polyclonal antibody against AIRE. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Autre désignation AIRE (AIRE Antibody Extrait)
Sujet AIRE is a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).
Alias Symbols: APS1, APSI, PGA1, AIRE1, APECED
Protein Interaction Partner: TUBB, RAVER1, TUBA1C, TMPRSS13, CCDC87, FAT1, GIGYF2, SRRM2, TUBB4B, EIF4EBP3, UBB, HSP90AB1, HSPA8, HSPA5, HSPA1L, HSPA1A, ATP4A, HIST3H3, HDAC2, HDAC1, DAXX, AIRE, UBAC1, HIST1H3A, HIST2H2BE, HSPA4, SRSF1, SMC1A, XPO1, TOP2A, SSRP1, SNRPD3, SNRPB, SRSF3
Protein Size: 545
Poids moléculaire 58 kDa
ID gène 326
NCBI Accession NM_000383, NP_000374
UniProt O43918
Pathways Chromatin Binding
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 545 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-Autoimmune Regulator (AIRE) (N-Term) antibody (ABIN2779776) anti-Autoimmune Regulator (AIRE) (N-Term) antibody
Produit citée dans: Tao, Kupfer, Stewart, Williams-Skipp, Crowell, Patel, Sain, Scheinman: "AIRE recruits multiple transcriptional components to specific genomic regions through tethering to nuclear matrix." dans: Molecular immunology, Vol. 43, Issue 4, pp. 335-45, 2005 (PubMed).

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