ACD anticorps (C-Term)

N° du produit ABIN2779815

Cet anticorps Lapin Polyclonal détecte spécifiquement ACD dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye et Cheval.

Aperçu rapide pour ACD anticorps (C-Term) (ABIN2779815)

Antigène: ACD (Adrenocortical Dysplasia Homolog (ACD))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ACD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ACD anticorps

Épitope: C-Term

Fonction: Acd Antibody - C-terminal region

Séquence: PRTSAQELCS VWEPPERHRD TSAFQYKYET PSASLHTQVQ TARLSPQLVA

Homologie: Cow: 83%, Dog: 85%, Guinea Pig: 85%, Horse: 85%, Human: 85%, Mouse: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against Acd. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the c terminal region of mouse Acd

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP36813-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ACD

Antigène: ACD (Adrenocortical Dysplasia Homolog (ACD))

Autre désignation: Acd

Sujet:

Background Information: Acd is a component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends, without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways.Acd promotes binding of POT1 to single-stranded telomeric DNA.Acd modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomer elongation by increasing telomerase processivity.Acd plays a role in shelterin complex assembly. Acd may play an essential role in organogenesis of the developing embryo.

Gene Name: Adrenocortical dysplasia

Alternative Symbols: -

Protein Name: Adrenocortical dysplasia protein

Poids moléculaire: 45

ID gène: 497652

NCBI Accession: NP_001012656

UniProt: Q5EE38

Pathways: Telomere Maintenance