MCAF1 anticorps (Middle Region)

N° du produit ABIN2780013

Détail du produit anti-MCAF1 anticorps

Antigène: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Épitope: Middle Region

Reactivité: Porc, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCAF1 est non-conjugé

Application: Western Blotting (WB)

Séquence: MSTPEGEKSE KDGKAEEEER VPAEEQPPVR NEFSRRKRSK SEDMDSVESK

Homologie: Mouse: 100%, Pig: 92%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against Atf7ip. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Mouse Atf7ip

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1306 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCAF1

Antigène: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Autre désignation: Atf7ip (ATF7IP Produits)

Synonymes: anticorps ATF7IP, anticorps AM, anticorps MCAF, anticorps MCAF1, anticorps p621, anticorps 2610204M12Rik, anticorps Mcaf1, anticorps fa12g02, anticorps wu:fa12g02, anticorps zgc:152981, anticorps activating transcription factor 7 interacting protein, anticorps Atf7ip, anticorps ATF7IP, anticorps atf7ip

Sujet: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.
Alias Symbols: 2610204M12Rik, AM, Mcaf1
Protein Interaction Partner: Atf7, Gtf2f1, Gtf2e2, Aagab, Ccnh, Gtf2h1, Ercc3, Cdk7, C1qbp, POLR2H, POLR2G, POLR2D, POLR2C,
Protein Size: 1306

Poids moléculaire: 138 kDa

ID gène: 54343

NCBI Accession: NM_019426, NP_062299

UniProt: Q7TT18