MCAF1 anticorps (Middle Region)

N° du produit ABIN2780013

Cet anticorps anti-MCAF1 Polyclonal Lapin (ABIN2780013) détecte spécifiquement MCAF1 dans WB. L’anticorps est réactif avec des échantillons de Porc, Souris et Rat.

Aperçu rapide pour MCAF1 anticorps (Middle Region) (ABIN2780013)

Antigène: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Reactivité: Porc, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MCAF1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MCAF1 anticorps

Épitope: Middle Region

Fonction: Atf7ip Antibody - middle region

Séquence: MSTPEGEKSE KDGKAEEEER VPAEEQPPVR NEFSRRKRSK SEDMDSVESK

Homologie: Mouse: 100%, Pig: 92%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against Atf7ip. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Mouse Atf7ip

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37246-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur MCAF1

Antigène: MCAF1 (ATF7IP) (Activating Transcription Factor 7 Interacting Protein (ATF7IP))

Autre désignation: Atf7ip

Sujet:

Background Information: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.

Gene Name: activating transcription factor 7 interacting protein

Alternative Symbols: A, AM, Mcaf, Mcaf1, 2610204M12Rik, 5830415B17Rik

Protein Name: Activating transcription factor 7-interacting protein 1

Poids moléculaire: 138kDa

ID gène: 54343

NCBI Accession: NP_062299

UniProt: Q7TT18