NMRAL1 anticorps (N-Term)

N° du produit ABIN2780056

Cet anticorps Lapin Polyclonal détecte spécifiquement NMRAL1 dans WB. Il présente une réactivité envers Rat, Souris, Boeuf (Vache), Chien et Porc.

Aperçu rapide pour NMRAL1 anticorps (N-Term) (ABIN2780056)

Antigène: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Reactivité: Rat, Souris, Boeuf (Vache), Chien, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NMRAL1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NMRAL1 anticorps

Épitope: N-Term

Séquence: GATGAQGGSV ARALLEDGTF RIRVVTRNPE QRAAKELKQQ GAEVVRGDQD

Homologie: Cow: 79%, Dog: 79%, Mouse: 100%, Pig: 86%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against Nmral1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the n terminal region of mouse Nmral1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 309 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NMRAL1

Antigène: NMRAL1 (NmrA-Like Family Domain Containing 1 (NMRAL1))

Autre désignation: Nmral1

Sujet: Nmral1 is a redox sensor protein. Nmral1 undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP+ levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH.Nmral1 has higher affinity for NADPH than for NADP+. Binding to NADPH is necessary to form a stable dimer.
Alias Symbols: 1110025F24Rik, AI256624
Protein Size: 309

Poids moléculaire: 34 kDa

ID gène: 67824

NCBI Accession: NM_026393, NP_080669

UniProt: Q8K2T1