PPARD anticorps (N-Term)

N° du produit ABIN2780303

Cité dans 4 publications. Cet anticorps anti-PPARD Polyclonal Lapin (ABIN2780303) détecte spécifiquement PPARD dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval et Lapin.

Aperçu rapide pour PPARD anticorps (N-Term) (ABIN2780303)

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PPARD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PPARD anticorps

Épitope: N-Term

Fonction: PPARD Antibody - N-terminal region

Séquence: FGRMPEAEKR KLVAGLTASE GCQHNPQLAD LKAFSKHIYN AYLKNFNMTK

Homologie: Cow: 85%, Dog: 93%, Guinea Pig: 100%, Horse: 93%, Human: 93%, Mouse: 100%, Rabbit: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PPARD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of mouse PPARD

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37889-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PPARD (ABIN2780303)

Kramerova, Ermolova, Eskin, Hevener, Quehenberger, Armando, Haller, Romain, Nelson, Spencer: "Failure to up-regulate transcription of genes necessary for muscle adaptation underlies limb girdle muscular dystrophy 2A (calpainopathy)." dans: Human molecular genetics, Vol. 25, Issue 11, pp. 2194-2207, (2016) (PubMed).

Ares-Carrasco, Picatoste, Camafeita, Carrasco-Navarro, Zubiri, Ortiz, Egido, López, Tuñón, Lorenzo: "Proteome changes in the myocardium of experimental chronic diabetes and hypertension: role of PPAR? in the associated hypertrophy." dans: Journal of proteomics, Vol. 75, Issue 6, pp. 1816-29, (2012) (PubMed).

Yang, Zhang, Zhou, Yan, Adell, Sun: "Biological function and prognostic significance of peroxisome proliferator-activated receptor ? in rectal cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 11, pp. 3760-70, (2011) (PubMed).

Yang, Olsson, Pfeifer, Jönsson, Zhou, Jiang, Fredriksson, Zhang, Sun: "Knockdown of peroxisome proliferator-activated receptor-beta induces less differentiation and enhances cell-fibronectin adhesion of colon cancer cells." dans: Oncogene, Vol. 29, Issue 4, pp. 516-26, (2010) (PubMed).

Détails sur PPARD

Antigène: PPARD (Peroxisome Proliferator-Activated Receptor delta (PPARD))

Autre désignation: PPARD

Sujet:

Background Information: PPARdelta is pivotal to control the program for fatty acid oxidation in the skeletal muscle, thereby ameliorating obesity and insulin resistance through its activation in obese animals.

Gene Name: Peroxisome proliferator activator receptor delta

Alternative Symbols: P, NUC, Nr1, Ppa, NUC1, PPAR, NUC-1, Nr1c2, Pparb, PPAR[b], Pparb/d, PPAR-beta, PPARdelta, PPAR-delta

Protein Name: Peroxisome proliferator-activated receptor delta

Poids moléculaire: 48kDa

ID gène: 19015

NCBI Accession: NP_035275

UniProt: P35396

Pathways: Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Monocarboxylic Acid Catabolic Process, Smooth Muscle Cell Migration, Positive Regulation of fat Cell Differentiation