JunB anticorps (C-Term)

N° du produit ABIN2780414

Cet anticorps anti-JunB Polyclonal Lapin (ABIN2780414) détecte spécifiquement JunB dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Mouton, Cheval, Cobaye, Poisson zèbre (Danio rerio), Chévre, Lapin et Saccharomyces cerevisiae.

Aperçu rapide pour JunB anticorps (C-Term) (ABIN2780414)

Antigène: JunB (JUNB) (Jun B Proto-Oncogene (JUNB))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Mouton, Cheval, Cobaye, Poisson zèbre (Danio rerio), Chévre, Lapin, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JunB est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-JunB anticorps

Épitope: C-Term

Fonction: JUNB Antibody - C-terminal region

Séquence: VERKRLRNRL AATKCRKRKL ERIARLEDKV KTLKAENAGL SSTAGLLREQ

Homologie: Cow: 100%, Dog: 100%, Goat: 85%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 85%, Rat: 100%, Sheep: 100%, Yeast: 91%, Zebrafish: 85%

Attributs du produit: This is a rabbit polyclonal antibody against JUNB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human JUNB

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8103565

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur JunB

Antigène: JunB (JUNB) (Jun B Proto-Oncogene (JUNB))

Autre désignation: JUNB

Sujet:

Background Information: The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-Jun oncogene. The c-Jun protein, along with c-Fos, is a component of the AP-1 transcriptional complex. c-Jun can form either Jun/Jun homodimers or Jun/Fos heterodimers via the leucine repeats in both proteins. Jun B and Jun D, have been shown to be almost identical to c-Jun in their C-terminal regions, which are involved in dimerization and DNA binding, whereas their N-terminal domains, which are involved in transcriptional activation, diverge. JunB is involved in many types of human carcinoma including T-cell lymphomas, CML,primary cutaneous lymphomas. Aberrantly expressed c-Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF-kappa B. JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction.JunB is an important regulator of erythroid Differentiation.

Gene Name: Jun B proto-oncogene

Alternative Symbols: AP-1

Protein Name: Transcription factor jun-B

Poids moléculaire: 36kDa

ID gène: 3726

NCBI Accession: NP_002220

UniProt: P17275