ZFP36 anticorps (Middle Region)

N° du produit ABIN2780505

L’anticorps anti-ZFP36 Polyclonal Lapin est utilisé pour la détection de ZFP36 dans des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin et Mouton. Il a été validé pour WB et IHC.

Aperçu rapide pour ZFP36 anticorps (Middle Region) (ABIN2780505)

Antigène: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cobaye, Lapin, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFP36 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ZFP36 anticorps

Épitope: Middle Region

Séquence: PSCRRATPIS VWGPLGGLVR TPSVQSLGSD PDEYASSGSS LGGSDSPVFE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ZFP36. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ZFP36

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 326 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ZFP36

Antigène: ZFP36 (Zinc Finger Protein 36, C3H Type, Homolog (Mouse) (ZFP36))

Autre désignation: ZFP36

Sujet: ZFP36 is a probable regulatory protein with a novel zinc finger structure involved in regulating the response to growth factors. Knockdown of ZFP36 increased both cognate macrophage gene mRNAs and inflammatory tumor necrosis factor protein release. Overexpression of ZFP36 resulted in decreased levels of the same genes supporting its role in regulating macrophage gene expression. Multiple phosphorylation sites in ZFP36 in mammalian cells were reported. ZFP36 can be phosphorylated by JNK as well as by the other members of the greater MAP kinase family. Gene expression profiling predicts clinical outcome of prostate cancer. Inappropriate ZFP36 production may be one factor that contributes to higher rheumatoid arthritis disease activity.
Alias Symbols: G0S24, GOS24, NUP475, RNF162A, TIS11, TTP
Protein Interaction Partner: YWHAB, PPP2CA, DNAJB1, DCP1B, DHX36, PRR5L, XRN1, UBC, TRAF2, EXOSC6, UPF2, EXOSC8, YWHAQ, TNF, DCP2, EDC3, DCP1A, EDC4, CDK6, APP, LIN28A, SH3KBP1, PABPC1, NCL, MAP3K4, HSPA4, HDAC7, HDAC3, NFKB1, HOXC9, HDAC1, CCDC85B, MAPKAPK2, YWHAG, SFN, HMGB1, NUP21
Protein Size: 326

Poids moléculaire: 34 kDa

ID gène: 7538

NCBI Accession: NM_003407, NP_003398

UniProt: P26651