ETS2 anticorps (N-Term)

N° du produit ABIN2780664

Cet anticorps Lapin Polyclonal détecte spécifiquement ETS2 dans WB. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval et Lapin.

Aperçu rapide pour ETS2 anticorps (N-Term) (ABIN2780664)

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ETS2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ETS2 anticorps

Épitope: N-Term

Fonction: ETS2 Antibody - N-terminal region

Séquence: NDFGIKNMDQ VAPVANSYRG TLKRQPAFDT FDGSLFAVFP SLNEEQTLQE

Homologie: Cow: 93%, Dog: 93%, Horse: 86%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ETS2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ETS2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP38591-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ETS2

Antigène: ETS2 (V-Ets Erythroblastosis Virus E26 Oncogene Homolog 2 (ETS2))

Autre désignation: ETS2

Sujet:

Background Information: ETS2 contains an ETS DNA-binding domain and belongs to the ETS family. ETS2 is a target of protein kinase C and upregulates GM-CSF. Ets2 and its targets play essential roles in endothelial cell function. Coexpression of Ets-2 and SRC-1 significantly associated with the rate of recurrence and HER expression in breast cancer. Overexpression of ETS2 is associated with human esophageal squamous cell carcinoma.ETS transcriptions factors, such as ETS2, regulate numerous genes and are involved in stem cell development, cell senescence and death, and tumorigenesis. The conserved ETS domain within these proteins is a winged helix-turn-helix DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T of target genes (Dwyer et al., 2007 [PubMed 17986575]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: V-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Alternative Symbols: ETS2IT1

Protein Name: Protein C-ets-2

Poids moléculaire: 53kDa

ID gène: 2114

NCBI Accession: NP_005230

UniProt: P15036

Pathways: EGFR Signaling Pathway, Myometrial Relaxation and Contraction