RBM5 anticorps (N-Term)

N° du produit ABIN2780715

Cet anticorps Lapin Polyclonal détecte spécifiquement RBM5 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye et Saccharomyces cerevisiae.

Aperçu rapide pour RBM5 anticorps (N-Term) (ABIN2780715)

Antigène: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RBM5 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RBM5 anticorps

Épitope: N-Term

Séquence: GSDKRVSRTE RSGRYGSIID RDDRDERESR SRRRDSDYKR SSDDRRGDRY

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 80%

Attributs du produit: This is a rabbit polyclonal antibody against RBM5. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RBM5

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 815 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RBM5

Antigène: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Autre désignation: RBM5

Sujet: RBM5 is a component of the spliceosome A complex.It regulates alternative splicing of a number of mRNAs. RBM5 may modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. RBM5 may both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, RBM5 promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis.
Alias Symbols: FLJ39876, G15, H37, LUCA15, RMB5
Protein Interaction Partner: UBC, RNF2, SUZ12, WDR77, WBP11, LSM8, PRPF19, U2SURP, SNRNP200, U2AF2, PRPF8, ILF3, DHX15, LIG4, COPS5, SF3A2, SUMO2, GAPDH, BCL2L1, LRIF1,
Protein Size: 815

Poids moléculaire: 92 kDa

ID gène: 10181

NCBI Accession: NM_005778, NP_005769

UniProt: P52756

Pathways: Ribonucleoprotein Complex Subunit Organization