SIX Homeobox 1 anticorps (N-Term)

N° du produit ABIN2780732

Détail du produit anti-SIX Homeobox 1 anticorps

Antigène: SIX Homeobox 1 (SIX1)

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Mouton, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIX Homeobox 1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: ERLGRFLWSL PACDHLHKNE SVLKAKAVVA FHRGNFRELY KILESHQFSP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against Six1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 284 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SIX Homeobox 1

Antigène: SIX Homeobox 1 (SIX1)

Autre désignation: Six1 (SIX1 Produits)

Synonymes: anticorps BOS3, anticorps DFNA23, anticorps TIP39, anticorps BB138287, anticorps six1b, anticorps six2, anticorps zgc:92332, anticorps XSix1, anticorps six1, anticorps zgc:77345, anticorps SIX homeobox 1, anticorps sine oculis-related homeobox 1, anticorps SIX homeobox 1a, anticorps SIX homeobox 1 L homeolog, anticorps SIX homeobox 1b, anticorps SIX1, anticorps Six1, anticorps six1a, anticorps six1.L, anticorps six1b

Sujet: Six1 is a transcription factor that is involved in regulation of organogenesis. It seems to be required for development of kidney, muscle and inner ear and to be involved in later steps of myogenic differentiation. It may be involved in limb tendon and ligament development. It binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter. It is thought to be regulated by association with Dach and Eya proteins. Six1 acts as activator of the IGFBP5 promoter, probably coactivated by EYA2. Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 phosphatase to the SIX1-DACH1 complex. During myogenesis, Six1 seems to act together with EYA2 and DACH2 .
Alias Symbols: BB138287
Protein Interaction Partner: Eya4, Eya1, Smarca4, Neurog1, Neurod1, Smarcc2, Sox2, Smarcc1, Eya3, Dach1,
Protein Size: 284

Poids moléculaire: 32 kDa

ID gène: 20471

NCBI Accession: NM_009189, NP_033215

UniProt: Q62231

Pathways: Sensory Perception of Sound, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development