HBP1 anticorps (Middle Region)

N° du produit ABIN2780873

Détail du produit anti-HBP1 anticorps

Antigène: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Lapin, Cheval, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HBP1 est non-conjugé

Application: Western Blotting (WB)

Séquence: SVILGDRWKK MKNEERRMYT LEAKALAEEQ KRLNPDCWKR KRTNSGSQQH

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against HBP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human HBP1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 514 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-HBP1 (ABIN2780873)

Wang, Pan, Chen, Huang, Zhang: "The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression." dans: Nucleic acids research, Vol. 40, Issue 3, pp. 981-95, (2012) (PubMed).

Li, Bian, Liao, Li, Zhao: "miR-17-5p promotes human breast cancer cell migration and invasion through suppression of HBP1." dans: Breast cancer research and treatment, Vol. 126, Issue 3, pp. 565-75, (2011) (PubMed).

Détails sur HBP1

Antigène: HBP1 (HMG Box-Containing Protein 1 (HBP1))

Autre désignation: HBP1 (HBP1 Produits)

Synonymes: anticorps 1700058O05Rik, anticorps BE629963, anticorps C330012F01Rik, anticorps C86454, anticorps hbp1-B, anticorps Hmgb1, anticorps wu:fj62c10, anticorps zgc:112297, anticorps high mobility group box transcription factor 1, anticorps HMG-box transcription factor 1, anticorps HMG-box transcription factor 1 L homeolog, anticorps Hbp1, anticorps HBP1, anticorps hbp1.L, anticorps hbp1

Sujet: HBP1 is a transcriptional repressor that binds to the promoter region of target genes. This protein plays a role in the regulation of the cell cycle and of the Wnt pathway. It binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter, HBP1 is enhanced by interaction with RB1. The protein also can disrupt the interaction between DNA and TCF4.
Alias Symbols: FLJ16340
Protein Interaction Partner: FBXW11, UBC, TMEM37, SMAD1, ZNF212, KIAA1279, EWSR1, CD2AP, EP300, CREBBP, MYC, ANKRD2, SIN3A, SAP30, TCF4, HDAC1, RBL2, RB1,
Protein Size: 514

Poids moléculaire: 58 kDa

ID gène: 26959

NCBI Accession: NM_012257, NP_036389

UniProt: O60381