OPTN anticorps (N-Term)

N° du produit ABIN2781170

L’anticorps Lapin Polyclonal anti-OPTN a été validé pour WB et IHC. Il convient pour détecter OPTN dans des échantillons de Humain, Rat, Chien, Cobaye, Boeuf (Vache) et Cheval.

Aperçu rapide pour OPTN anticorps (N-Term) (ABIN2781170)

Antigène: OPTN (Optineurin (OPTN))

Reactivité: Humain, Rat, Chien, Cobaye, Boeuf (Vache), Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-OPTN anticorps

Épitope: N-Term

Séquence: SHQPLSCLTE KEDSPSESTG NGPPHLAHPN LDTFTPEELL QQMKELLTEN

Homologie: Cow: 86%, Dog: 83%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against OPTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human OPTN

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 577 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN

Sujet: OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins.This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
Alias Symbols: FIP2, GLC1E, HIP7, HYPL, NRP, TFIIIA-INTP, ALS12
Protein Interaction Partner: RAB10, TNIP1, OPTN, DAZAP2, CDC23, UBC, PARK2, ZNF670, ZNF329, TBC1D15, ZNF398, CCDC53, MAP1LC3A, TBC1D17, HACE1, RAB25, RAB11B, SQSTM1, RAB11A, Rab8a, Tfrc, BRE, FAM178A, UQCRQ, GNAS, RAB12, EPS15, RAB14, MAP1LC3B, PIAS4, RNF11, RIPK1, TNFRSF1A, TNF, HTT
Protein Size: 577

Poids moléculaire: 66 kDa

ID gène: 10133

NCBI Accession: NM_001008213, NP_001008214

UniProt: Q96CV9

Pathways: M Phase