OPTN anticorps (C-Term)

N° du produit ABIN2781486

Cet anticorps anti-OPTN Polyclonal Lapin (ABIN2781486) détecte spécifiquement OPTN dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour OPTN anticorps (C-Term) (ABIN2781486)

Antigène: OPTN (Optineurin (OPTN))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Boeuf (Vache), Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp OPTN est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-OPTN anticorps

Épitope: C-Term

Fonction: OPTN Antibody - C-terminal region

Séquence: SDQQAYLVQR GAEDRDWRQQ RNIPIHSCPK CGEVLPDIDT LQIHVMDCII

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 92%

Attributs du produit: This is a rabbit polyclonal antibody against OPTN. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human OPTN

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP43601-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur OPTN

Antigène: OPTN (Optineurin (OPTN))

Autre désignation: OPTN

Sujet:

Background Information: OPTN is the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Gene Name: Optineurin

Alternative Symbols: NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP

Protein Name: Optineurin

Poids moléculaire: 66 kDa

ID gène: 10133

NCBI Accession: NP_068815

UniProt: Q96CV9

Pathways: M Phase