HFE anticorps (C-Term)

N° du produit ABIN2781800

Détail du produit anti-HFE anticorps

Antigène: HFE (Hemochromatosis (HFE))

Épitope: C-Term

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Cheval, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HFE est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: FEPKDVLPNG DGTYQGWITL AVPPGEEQRY TCQVEHPGLD QPLIVIWEPS

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 92%, Horse: 86%, Human: 100%, Rat: 100%, Zebrafish: 91%

Attributs du produit: This is a rabbit polyclonal antibody against HFE. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human HFE

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 246 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HFE

Antigène: HFE (Hemochromatosis (HFE))

Autre désignation: HFE (HFE Produits)

Synonymes: anticorps HFE1, anticorps HH, anticorps HLA-H, anticorps MVCD7, anticorps TFQTL2, anticorps MR2, anticorps hemochromatosis, anticorps HFE, anticorps Hfe

Sujet: HFE is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in its gene.The protein encoded by this gene is a membrane protein that is similar to MHC class I-type proteins and associates with beta2-microglobulin (beta2M). It is thought that this protein functions to regulate iron absorption by regulating the interaction of the transferrin receptor with transferrin. The iron storage disorder, hereditary haemochromatosis, is a recessive genetic disorder that results from defects in this gene. At least eleven alternatively spliced variants have been described for this gene. Additional variants have been found but their full-length nature has not been determined.
Alias Symbols: HFE1, HH, HLA-H, MGC103790, dJ221C16.10.1, MVCD7, TFQTL2
Protein Interaction Partner: B2M, SYVN1, UBC, TFR2, TFRC,
Protein Size: 246

Poids moléculaire: 28 kDa

ID gène: 3077

NCBI Accession: NM_139008, NP_620577

Pathways: Transition Metal Ion Homeostasis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process