Ectodysplasin A anticorps (Middle Region)

N° du produit ABIN2781905

Il existe 1 publication pour ce produit. L’anticorps anti-Ectodysplasin A Polyclonal Lapin est utilisé pour la détection de Ectodysplasin A dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Chévre, Cobaye, Cheval et Lapin. Il a été validé pour WB.

Aperçu rapide pour Ectodysplasin A anticorps (Middle Region) (ABIN2781905)

Antigène: Ectodysplasin A (EDA)

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Chévre, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ectodysplasin A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Ectodysplasin A anticorps

Épitope: Middle Region

Fonction: EDA Antibody - middle region

Séquence: HLQGQGSAIQ VKNDLSGGVL NDWSRITMNP KVFKLHPRSG ELEVLVDGTY

Homologie: Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against EDA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human EDA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44519-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-Ectodysplasin A (ABIN2781905)

Zhao, Watt, Battle, Li, Bondow, Duncan: "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice." dans: Developmental biology, Vol. 317, Issue 2, pp. 614-9, (2008) (PubMed).

Détails sur Ectodysplasin A

Antigène: Ectodysplasin A (EDA)

Autre désignation: EDA

Sujet:

Background Information: EDA is a type II membrane protein that can be cleaved by furin to produce a secreted form. It belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene.

Gene Name: Ectodysplasin A

Alternative Symbols: ED1, HED, EDA1, EDA2, HED1, ODT1, XHED, ECTD1, XLHED, ED1-A1, ED1-A2, EDA-A1, EDA-A2, TNLG7C, STHAGX1

Protein Name: Ectodysplasin-A

Poids moléculaire: 41kDa

ID gène: 1896

NCBI Accession: NP_001005609

UniProt: B7ZLU4

Pathways: Tube Formation