ITM2C anticorps (Middle Region)

N° du produit ABIN2781948

Cet anticorps anti-ITM2C est un anticorps Lapin Polyclonal détectant ITM2C dans WB. Adapté pour Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Mouton, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour ITM2C anticorps (Middle Region) (ABIN2781948)

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Mouton, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITM2C est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ITM2C anticorps

Épitope: Middle Region

Séquence: EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Attributs du produit: This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 267 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ITM2C

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Autre désignation: ITM2C

Sujet: ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Alias Symbols: BRI3, BRICD2C, E25, E25C, ITM3
Protein Interaction Partner: UBC, Dlg4, RYK, BACE1, RNF7, STT3A, MTNR1B, FURIN,
Protein Size: 267

Poids moléculaire: 30 kDa

ID gène: 81618

NCBI Accession: NM_030926, NP_112188

UniProt: Q9NQX7