SPPL2B anticorps (N-Term)

N° du produit ABIN2782090

Cet anticorps Lapin Polyclonal détecte spécifiquement SPPL2B dans WB et IHC. Il présente une réactivité avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Cheval, Porc, Chien et Cobaye.Il a été cité dans 1 publication.

Aperçu rapide pour SPPL2B anticorps (N-Term) (ABIN2782090)

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cheval, Porc, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPPL2B est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SPPL2B anticorps

Épitope: N-Term

Fonction: SPPL2B Antibody - N-terminal region

Séquence: VARGNCTFYE KVRLAQGSGA RGLLIVSRER LVPPGGNKTQ YDEIGIPVAL

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 86%, Rat: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SPPL2B. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SPPL2B

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8111707

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SPPL2B (ABIN2782090)

Del Campo, Hoozemans, Dekkers, Rozemuller, Korth, Müller-Schiffmann, Scheltens, Blankenstein, Jimenez, Veerhuis, Teunissen: "BRI2-BRICHOS is increased in human amyloid plaques in early stages of Alzheimer's disease." dans: Neurobiology of aging, Vol. 35, Issue 7, pp. 1596-604, (2014) (PubMed).

Détails sur SPPL2B

Antigène: SPPL2B (Signal Peptide Peptidase-Like 2B (SPPL2B))

Autre désignation: SPPL2B

Sujet:

Background Information: SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

Gene Name: Signal peptide peptidase like 2B

Alternative Symbols: IMP4, PSH4, PSL1, IMP-4

Protein Name: Signal peptide peptidase-like 2B

Poids moléculaire: 56kDa

ID gène: 56928

NCBI Accession: NP_001070706

UniProt: Q8TCT7