CDS1 anticorps (Middle Region)

N° du produit ABIN2782121

Cet anticorps Lapin Polyclonal détecte spécifiquement CDS1 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye et Cheval et a été mentionné dans 1 publication.

Aperçu rapide pour CDS1 anticorps (Middle Region) (ABIN2782121)

Antigène: CDS1 (CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 1 (CDS1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CDS1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-CDS1 anticorps

Épitope: Middle Region

Séquence: VVFGFIAAYV LSKYQYFVCP VEYRSDVNSF VTECEPSELF QLQTYSLPPF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CDS1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CDS1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 461 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-CDS1 (ABIN2782121)

Croston, Shepherd, Thapa, Nichols, Lewis, Dabkowski, Jagannathan, Baseler, Hollander: "Evaluation of the cardiolipin biosynthetic pathway and its interactions in the diabetic heart." dans: Life sciences, Vol. 93, Issue 8, pp. 313-22, (2013) (PubMed).

Détails sur CDS1

Antigène: CDS1 (CDP-Diacylglycerol Synthase (Phosphatidate Cytidylyltransferase) 1 (CDS1))

Autre désignation: CDS1

Sujet: Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. CDS1 is an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis.Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 and a second to 20p13.
Alias Symbols: CDS
Protein Interaction Partner: UBC, CDC25C,
Protein Size: 461

Poids moléculaire: 53 kDa

ID gène: 1040

NCBI Accession: NM_001263, NP_001254

UniProt: Q92903

Pathways: Inositol Metabolic Process