IL-10RA anticorps (N-Term)

N° du produit ABIN2782131

Cet anticorps Lapin Polyclonal détecte spécifiquement IL-10RA dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Boeuf (Vache), Cheval, Chien et Cobaye.

Aperçu rapide pour IL-10RA anticorps (N-Term) (ABIN2782131)

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Reactivité: Humain, Rat, Boeuf (Vache), Cheval, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp IL-10RA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-IL-10RA anticorps

Épitope: N-Term

Fonction: IL10RA Antibody - N-terminal region

Séquence: GSVNLEIHNG FILGKIQLPR PKMAPANDTY ESIFSHFREY EIAIRKVPGN

Homologie: Dog: 92%, Guinea Pig: 92%, Horse: 85%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against IL10RA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human IL10RA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8103325

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur IL-10RA

Antigène: IL-10RA (IL10RA) (Interleukin 10 Receptor, alpha (IL10RA))

Autre désignation: IL10RA

Sujet:

Targeted Subunit: alpha

Background Information: IL10RA is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.

Gene Name: Interleukin 10 receptor, alpha

Alternative Symbols: CD210, IL10R, CD210a, CDW210A, HIL-10R, IL-10R1

Protein Name: Interleukin-10 receptor subunit alpha

Poids moléculaire: 61kDa

ID gène: 3587

NCBI Accession: NP_001549

UniProt: Q13651

Pathways: Growth Factor Binding