Fc epsilon RI/FCER1A anticorps (N-Term)

N° du produit ABIN2782150

Cet anticorps anti-Fc epsilon RI/FCER1A est un anticorps Lapin Polyclonal détectant Fc epsilon RI/FCER1A dans WB. Adapté pour Humain.

Aperçu rapide pour Fc epsilon RI/FCER1A anticorps (N-Term) (ABIN2782150)

Antigène: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fc epsilon RI/FCER1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Fc epsilon RI/FCER1A anticorps

Épitope: N-Term

Séquence: NPPWNRIFKG ENVTLTCNGN NFFEVSSTKW FHNGSLSEET NSSLNIVNAK

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against FCER1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human FCER1A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 257 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Fc epsilon RI/FCER1A

Antigène: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Autre désignation: FCER1A

Sujet: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139), only the alpha subunit is glycosylated.
Alias Symbols: FCE1A, FcERI
Protein Interaction Partner: PDHB, SYK, FCER1A, FCER1G, MS4A2, ITIH2, VAV1,
Protein Size: 257

Poids moléculaire: 27 kDa

ID gène: 2205

NCBI Accession: NM_002001, NP_001992

UniProt: P12319

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process