Fc epsilon RI/FCER1A anticorps (Middle Region)

N° du produit ABIN2782151

Cet anticorps anti-Fc epsilon RI/FCER1A Polyclonal Lapin (ABIN2782151) détecte spécifiquement Fc epsilon RI/FCER1A dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat et Lapin.

Aperçu rapide pour Fc epsilon RI/FCER1A anticorps (Middle Region) (ABIN2782151)

Antigène: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Reactivité: Humain, Rat, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fc epsilon RI/FCER1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Fc epsilon RI/FCER1A anticorps

Épitope: Middle Region

Fonction: FCER1A Antibody - middle region

Séquence: IYYKDGEALK YWYENHNISI TNATVEDSGT YYCTGKVWQL DYESEPLNIT

Homologie: Human: 100%, Rabbit: 85%, Rat: 77%

Attributs du produit: This is a rabbit polyclonal antibody against FCER1A. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human FCER1A

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45205-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Fc epsilon RI/FCER1A

Antigène: Fc epsilon RI/FCER1A (FCER1A) (Fc Fragment of IgE Receptor Ia (FCER1A))

Autre désignation: FCER1A

Sujet:

Targeted Subunit: alpha

Background Information: The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139), only the alpha subunit is glycosylated.The IgE receptor plays a central role in allergic disease, coupling allergen and mast cell to initiate the inflammatory and immediate hypersensitivity responses that are characteristic of disorders such as hay fever and asthma. The allergic response occurs when 2 or more high-affinity IgE receptors are crosslinked via IgE molecules that in turn are bound to an allergen (antigen) molecule. A perturbation occurs that brings about the release of histamine and proteases from the granules in the cytoplasm of the mast cell and leads to the synthesis of prostaglandins and leukotrienes--potent effectors of the hypersensitivity response. The IgE receptor consists of 3 subunits: alpha, beta (MIM 147138), and gamma (MIM 147139), only the alpha subunit is glycosylated.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Fc fragment of IgE, high affinity I, receptor for, alpha polypeptide

Alternative Symbols: FCE1A, FcERI

Protein Name: High affinity immunoglobulin epsilon receptor subunit alpha

Poids moléculaire: 27kDa

ID gène: 2205

NCBI Accession: NP_001992

UniProt: P12319

Pathways: Fc-epsilon Receptor Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process