PIGA anticorps (Middle Region)

N° du produit ABIN2782189

Il existe 1 publication pour ce produit. L’anticorps anti-PIGA Polyclonal Lapin est utilisé pour la détection de PIGA dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin et Chien. Il a été validé pour WB.

Aperçu rapide pour PIGA anticorps (Middle Region) (ABIN2782189)

Antigène: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Porc, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PIGA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PIGA anticorps

Épitope: Middle Region

Fonction: PIGA Antibody - middle region

Séquence: SVKSLCEGLE KAIFQLKSGT LPAPENIHNI VKTFYTWRNV AERTEKVYDR

Homologie: Cow: 86%, Dog: 93%, Human: 100%, Mouse: 93%, Pig: 79%, Rabbit: 79%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against PIGA. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PIGA

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45344-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-PIGA (ABIN2782189)

Traulsen, Pacheco, Dingli: "On the origin of multiple mutant clones in paroxysmal nocturnal hemoglobinuria." dans: Stem cells (Dayton, Ohio), Vol. 25, Issue 12, pp. 3081-4, (2007) (PubMed).

Détails sur PIGA

Antigène: PIGA (Phosphatidylinositol Glycan Anchor Biosynthesis, Class A (PIGA))

Autre désignation: PIGA

Sujet:

Targeted Subunit: A

Background Information: PIGA is a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene.This gene encodes a protein required for synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the biosynthetic pathway of GPI anchor. The GPI anchor is a glycolipid found on many blood cells and which serves to anchor proteins to the cell surface. Paroxysmal nocturnal hemoglobinuria, an acquired hematologic disorder, has been shown to result from mutations in this gene. Alternate splice variants have been characterized.

Gene Name: Phosphatidylinositol glycan anchor biosynthesis, class A

Alternative Symbols: GPI3, PNH1, PIG-A, MCAHS2

Protein Name: Phosphatidylinositol N-acetylglucosaminyltransferase subunit A Ensembl ENSP00000416102

Poids moléculaire: 19kDa

ID gène: 5277

NCBI Accession: NP_065206

UniProt: B3KUV7

Pathways: Inositol Metabolic Process