TIM3 anticorps (N-Term)
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- Antigène Voir toutes TIM3 (TIM 3) Anticorps
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
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Épitope
- N-Term
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Reactivité
- Humain, Chien
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TIM3 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MFSHLPFDCV LLLLLLLLTR SSEVEYRAEV GQNAYLPCFY TPAAPGNLVP
- Homologie
- Dog: 79%, Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against HAVCR2. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human HAVCR2
- Top Product
- Discover our top product TIM 3 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 301 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- TIM3 (TIM 3) (Hepatitis A Virus Cellular Receptor 2 (TIM 3))
- Autre désignation
- HAVCR2 (TIM 3 Produits)
- Synonymes
- anticorps HAVCR2, anticorps MGC140131, anticorps HAVcr-2, anticorps KIM-3, anticorps TIM3, anticorps TIMD-3, anticorps TIMD3, anticorps Tim-3, anticorps TIM-3, anticorps Tim3, anticorps Timd3, anticorps tim3, anticorps hepatitis A virus cellular receptor 2, anticorps HAVCR2, anticorps Havcr2
- Classe de substances
- Virus
- Sujet
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HAVCR2 regulates macrophage activation. HAVCR2 inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. HAVCR2 may be also involved in T-cell homing. HAVCR2 is the receptor for LGALS9.CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: FLJ14428, KIM-3, TIM3, TIMD3, Tim-3, TIMD-3, HAVcr-2
Protein Interaction Partner: BAG6, LCK, APP, HAVCR2,
Protein Size: 301 - Poids moléculaire
- 33 kDa
- ID gène
- 84868
- NCBI Accession
- NM_032782, NP_116171
- UniProt
- Q8TDQ0
- Pathways
- Regulation of Lipid Metabolism by PPARalpha, Cancer Immune Checkpoints
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