BAAT anticorps (N-Term)

N° du produit ABIN2782317

Il existe 2+ publications pour ce produit. L’anticorps anti-BAAT Polyclonal Lapin est utilisé pour la détection de BAAT dans des échantillons de Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien et Cobaye. Il a été validé pour WB.

Aperçu rapide pour BAAT anticorps (N-Term) (ABIN2782317)

Antigène: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAAT est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-BAAT anticorps

Épitope: N-Term

Fonction: BAAT Antibody - N-terminal region

Séquence: IQLTATPVSA LVDEPVHIRA TGLIPFQMVS FQASLEDENG DMFYSQAHYR

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against BAAT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BAAT

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP45686-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BAAT (ABIN2782317)

Aleksunes, Yeager, Wen, Cui, Klaassen: "Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 130, Issue 2, pp. 257-68, (2012) (PubMed).

Tougou, Fukuda, Ito, Yamazaki, Fujio, Azuma: "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals." dans: Drug metabolism and pharmacokinetics, Vol. 22, Issue 2, pp. 125-8, (2007) (PubMed).

Détails sur BAAT

Antigène: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Autre désignation: BAAT

Sujet:

Background Information: BAAT is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.

Gene Name: Bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)

Alternative Symbols: BAT, HCHO, BACAT, BACD1

Protein Name: Bile acid-CoA:amino acid N-acyltransferase

Poids moléculaire: 46 kDa

ID gène: 570

NCBI Accession: NP_001692

UniProt: Q14032