BAAT anticorps (N-Term)

N° du produit ABIN2782317

Détail du produit anti-BAAT anticorps

Antigène: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cheval, Lapin, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAAT est non-conjugé

Application: Western Blotting (WB)

Séquence: IQLTATPVSA LVDEPVHIRA TGLIPFQMVS FQASLEDENG DMFYSQAHYR

Homologie: Cow: 86%, Dog: 93%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against BAAT. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human BAAT

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 418 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-BAAT (ABIN2782317)

Aleksunes, Yeager, Wen, Cui, Klaassen: "Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy." dans: Toxicological sciences : an official journal of the Society of Toxicology, Vol. 130, Issue 2, pp. 257-68, (2012) (PubMed).

Tougou, Fukuda, Ito, Yamazaki, Fujio, Azuma: "Genetic polymorphism of bile acid CoA: amino acid N-acyltransferase in Japanese individuals." dans: Drug metabolism and pharmacokinetics, Vol. 22, Issue 2, pp. 125-8, (2007) (PubMed).

Détails sur BAAT

Antigène: BAAT (Bile Acid CoA: Amino Acid N-Acyltransferase (Glycine N-Choloyltransferase) (BAAT))

Autre désignation: BAAT (BAAT Produits)

Synonymes: anticorps BACAT, anticorps BAT, anticorps AI118337, anticorps AI158864, anticorps kan-1, anticorps BAAT, anticorps bile acid-CoA:amino acid N-acyltransferase, anticorps Bile acid-CoA:amino acid N-acyltransferase, anticorps bile acid-Coenzyme A: amino acid N-acyltransferase, anticorps bile acid CoA:amino acid N-acyltransferase, anticorps BAAT, anticorps RPIC_RS10270, anticorps Bcav_2277, anticorps Rpic12D_1765, anticorps Baat, anticorps LOC481635, anticorps LOC100054567, anticorps LOC786798

Sujet: BAAT is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene.
Alias Symbols: BACAT, BAT, FLJ20300, MGC104432
Protein Interaction Partner: GOLGA8F, GOLGA8EP, GOLGA8DP, PEX5, SLC7A11,
Protein Size: 418

Poids moléculaire: 46 kDa

ID gène: 570

NCBI Accession: NM_001701, NP_001692

UniProt: Q14032