CSTB anticorps (Middle Region)

N° du produit ABIN2782349

L’anticorps Lapin Polyclonal anti-CSTB a été validé pour WB et IHC. Il convient pour détecter CSTB dans des échantillons de Humain, Rat, Souris, Cheval, Porc, Lapin et Chien.

Aperçu rapide pour CSTB anticorps (Middle Region) (ABIN2782349)

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivité: Humain, Rat, Souris, Cheval, Porc, Lapin, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSTB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CSTB anticorps

Épitope: Middle Region

Séquence: AGTNYFIKVH VGDEDFVHLR VFQSLPHENK PLTLSNYQTN KAKHDELTYF

Homologie: Dog: 92%, Horse: 85%, Human: 100%, Mouse: 83%, Pig: 79%, Rabbit: 77%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against CSTB. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human CSTB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 98 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CSTB

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Autre désignation: CSTB

Sujet: CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Alias Symbols: CST6, EPM1, PME, STFB, ULD, EPM1A
Protein Interaction Partner: UBC, SARNP, DPP7, BAG3, CFTR, ECT2, SEC24A, NUDC, MAT2A, FLNB, DCUN1D1, CUL3, RAD21, SPRY2, CTSL, CTSD, CTSH, CTSB, CST3, VHL,
Protein Size: 98

Poids moléculaire: 11 kDa

ID gène: 1476

NCBI Accession: NM_000100, NP_000091

UniProt: P04080

Pathways: Response to Water Deprivation