CSTB anticorps (N-Term)

N° du produit ABIN2782350

Cet anticorps anti-CSTB est un anticorps Lapin Polyclonal détectant CSTB dans WB et IHC. Adapté pour Humain, Rat, Souris, Boeuf (Vache), Cheval, Porc, Mouton, Lapin et Cobaye.

Aperçu rapide pour CSTB anticorps (N-Term) (ABIN2782350)

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Reactivité: Humain, Rat, Souris, Boeuf (Vache), Cheval, Porc, Mouton, Lapin, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CSTB est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-CSTB anticorps

Épitope: N-Term

Séquence: MMCGAPSATQ PATAETQHIA DQVRSQLEEK ENKKFPVFKA VSFKSQVVAG

Homologie: Cow: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 93%, Rabbit: 79%, Rat: 86%, Sheep: 100%

Attributs du produit: This is a rabbit polyclonal antibody against CSTB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human CSTB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 98 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur CSTB

Antigène: CSTB (Cystatin B (Stefin B) (CSTB))

Autre désignation: CSTB

Sujet: CSTB is a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in CSTB gene are responsible for the primary defects in patients with progressive myoclonic epilepsy a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy.The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1).
Alias Symbols: CST6, EPM1, PME, STFB, ULD, EPM1A
Protein Interaction Partner: UBC, SARNP, DPP7, BAG3, CFTR, ECT2, SEC24A, NUDC, MAT2A, FLNB, DCUN1D1, CUL3, RAD21, SPRY2, CTSL, CTSD, CTSH, CTSB, CST3, VHL,
Protein Size: 98

Poids moléculaire: 11 kDa

ID gène: 1476

NCBI Accession: NM_000100, NP_000091

UniProt: P04080

Pathways: Response to Water Deprivation