RRM1 anticorps (N-Term)

N° du produit ABIN2782439

Cet anticorps anti-RRM1 est un anticorps Lapin Polyclonal détectant RRM1 dans WB. Adapté pour Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Lapin, Cheval, Cobaye, Boeuf (Vache) et Saccharomyces cerevisiae.

Aperçu rapide pour RRM1 anticorps (N-Term) (ABIN2782439)

Antigène: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Lapin, Cheval, Cobaye, Boeuf (Vache), Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RRM1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-RRM1 anticorps

Épitope: N-Term

Séquence: ATGSYIAGTN GNSNGLVPML RVYNNTARYV DQGGNKRPGA FAIYLEPWHL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RRM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human RRM1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 792 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RRM1

Antigène: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Autre désignation: RRM1

Sujet: RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.
Alias Symbols: R1, RIR1, RR1
Protein Interaction Partner: UBC, RRM1, SUMO2, RNF2, BMI1, PPIB, TNPO1, FBXO6, PPP1CC, TMEM177, DNAJB11, SUCLA2, SGSH, NDUFV1, EEF2, DNASE2, COPS5, CDK2, RRM2, RRM2B, KAT5, LRIF1, YWHAG,
Protein Size: 792

Poids moléculaire: 90 kDa

ID gène: 6240

NCBI Accession: NM_001033, NP_001024

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity