FXYD1 anticorps (N-Term)

N° du produit ABIN2782662

Cet anticorps anti-FXYD1 Polyclonal Lapin (ABIN2782662) détecte spécifiquement FXYD1 dans WB. L’anticorps est réactif avec des échantillons de Humain, Rat, Cobaye, Lapin, Boeuf (Vache), Chien, Cheval et Porc.

Aperçu rapide pour FXYD1 anticorps (N-Term) (ABIN2782662)

Antigène: FXYD1 (FXYD Domain Containing Ion Transport Regulator 1 (FXYD1))

Reactivité: Humain, Rat, Cobaye, Lapin, Boeuf (Vache), Chien, Cheval, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FXYD1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-FXYD1 anticorps

Épitope: N-Term

Fonction: FXYD1 Antibody - N-terminal region

Séquence: ASLGHILVFC VGLLTMAKAE SPKEHDPFTY DYQSLQIGGL VIAGILFILG

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 85%, Horse: 86%, Human: 100%, Pig: 86%, Rabbit: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against FXYD1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human FXYD1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP46562-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur FXYD1

Antigène: FXYD1 (FXYD Domain Containing Ion Transport Regulator 1 (FXYD1))

Autre désignation: FXYD1

Sujet:

Background Information: FXYD1 is a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity. Transcript variants with different 5' UTR sequences have been described in the literature.

Gene Name: FXYD domain containing ion transport regulator 1

Alternative Symbols: PLM

Protein Name: Phospholemman

Poids moléculaire: 10kDa

ID gène: 5348

NCBI Accession: NP_005022

UniProt: O00168