EBP anticorps (N-Term)

N° du produit ABIN2782722

Cet anticorps Lapin Polyclonal détecte spécifiquement EBP dans WB. Il présente une réactivité envers Humain, Souris, Rat, Cobaye, Boeuf (Vache), Chien, Cheval, Porc et Lapin.

Aperçu rapide pour EBP anticorps (N-Term) (ABIN2782722)

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Reactivité: Humain, Souris, Rat, Cobaye, Boeuf (Vache), Chien, Cheval, Porc, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EBP est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EBP anticorps

Épitope: N-Term

Séquence: LVIEGWFVLY YEDLLGDQAF LSQLWKEYAK GDSRYILGDN FTVCMETITA

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 86%, Horse: 93%, Human: 100%, Mouse: 85%, Pig: 93%, Rabbit: 93%, Rat: 85%

Attributs du produit: This is a rabbit polyclonal antibody against EBP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human EBP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 230 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur EBP

Antigène: EBP (Emopamil Binding Protein (Sterol Isomerase) (EBP))

Autre désignation: EBP

Sujet: EBP is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in EBP gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).Emopamil-binding protein (EBP) is an integral membrane protein of the endoplasmic reticulum. It is a high affinity binding protein for the antiischemic phenylalkylamine Ca2+ antagonist [3H]emopamil and the photoaffinity label [3H]azidopamil. It is similar to sigma receptors and may be a member of a superfamily of high affinity drug-binding proteins in the endoplasmic reticulum of different tissues. EBP shares structural features with bacterial and eukaryontic drug transporting proteins. It has four putative transmembrane segments and contains two conserved glutamate residues which may be involved in the transport of cationic amphiphilics. Another prominent feature of EBP is its high content of aromatic amino acid residues (>23 % ) in its transmembrane segments. These aromatic amino acid residues have been suggested to be involved in the drug transport by the P-glycoprotein. Mutations in this gene cause Chondrodysplasia punctata 2 (CDPX2, also known as Conradi-Hunermann syndrome).
Alias Symbols: CDPX2, CHO2, CPX, CPXD
Protein Interaction Partner: UBC, MITF, VKORC1, APP, ELAVL1, ESRRG, EBPL,
Protein Size: 230

Poids moléculaire: 26 kDa

ID gène: 10682

NCBI Accession: NM_006579, NP_006570

UniProt: Q15125