SIGLEC7 anticorps (Middle Region)

N° du produit ABIN2782809

Détail du produit anti-SIGLEC7 anticorps

Antigène: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Épitope: Middle Region

Reactivité: Humain, Boeuf (Vache), Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SIGLEC7 est non-conjugé

Application: Western Blotting (WB)

Séquence: WRSLTLYPSQ PSNPLVLELQ VHLGDEGEFT CRAQNSLGSQ HVSLNLSLQQ

Homologie: Cow: 85%, Dog: 100%, Guinea Pig: 86%, Horse: 92%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SIGLEC7. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SIGLEC7

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 467 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SIGLEC7 (ABIN2782809)

Jaroenpool, Rogers, Pattanapanyasat, Villinger, Onlamoon, Crocker, Ansari: "Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates." dans: Cellular immunology, Vol. 250, Issue 1-2, pp. 91-104, (2008) (PubMed).

Détails sur SIGLEC7

Antigène: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Autre désignation: SIGLEC7 (SIGLEC7 Produits)

Synonymes: anticorps SIGLEC7, anticorps AIRM1, anticorps CD328, anticorps CDw328, anticorps D-siglec, anticorps QA79, anticorps SIGLEC-7, anticorps SIGLEC19P, anticorps SIGLECP2, anticorps p75, anticorps p75/AIRM1, anticorps sialic acid-binding Ig-like lectin 7, anticorps sialic acid binding Ig like lectin 7, anticorps LOC468976, anticorps SIGLEC7

Sujet: SIGLEC7 is a putative adhesion molecule that mediates sialic-acid dependent binding to cells. In the immune response, it may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. SIGLEC7 mediates inhibition of natural killer cells cytotoxicity. It may also play a role in hemopoiesis. SIGLEC7 inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro).
Alias Symbols: AIRM1, CDw328, D-siglec, QA79, SIGLEC-7, p75, p75/AIRM1, CD328
Protein Interaction Partner: SOCS3, TRAF4, PTPN11, GRB2,
Protein Size: 467

Poids moléculaire: 51 kDa

ID gène: 27036

NCBI Accession: NM_014385, NP_055200

UniProt: Q9Y286