Seladin 1 anticorps (N-Term)

N° du produit ABIN2782831

L’anticorps anti-Seladin 1 Polyclonal Lapin est utilisé pour la détection de Seladin 1 dans des échantillons de Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye et Cheval. Il a été validé pour WB.

Aperçu rapide pour Seladin 1 anticorps (N-Term) (ABIN2782831)

Antigène: Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Seladin 1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Seladin 1 anticorps

Épitope: N-Term

Fonction: DHCR24 Antibody - N-terminal region

Séquence: FLLPLSLIFD IYYYVRAWVV FKLSSAPRLH EQRVRDIQKQ VREWKEQGSK

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against DHCR24. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human DHCR24

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47072-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur Seladin 1

Antigène: Seladin 1 (DHCR24) (24-Dehydrocholesterol Reductase (DHCR24))

Autre désignation: DHCR24

Sujet:

Background Information: DHCR24 is a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: 24-dehydrocholesterol reductase

Alternative Symbols: DCE, SELADIN1, Nbla03646, seladin-1

Protein Name: Delta(24)-sterol reductase

Poids moléculaire: 58kDa

ID gène: 1718

NCBI Accession: NP_055577

UniProt: Q15392