NAGPA anticorps (N-Term)

N° du produit ABIN2782884

Cet anticorps Lapin Polyclonal détecte spécifiquement NAGPA dans WB. Il présente une réactivité envers Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Rat et Poisson zèbre (Danio rerio).

Aperçu rapide pour NAGPA anticorps (N-Term) (ABIN2782884)

Antigène: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Reactivité: Humain, Boeuf (Vache), Chien, Cobaye, Cheval, Souris, Rat, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NAGPA est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-NAGPA anticorps

Épitope: N-Term

Séquence: GECLGNVVSD ERRVSSSGGL QNAQFGIRRD GTLVTGYLSE EEVLDTENPF

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against NAGPA. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human NAGPA

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur NAGPA

Antigène: NAGPA (N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA))

Autre désignation: NAGPA

Sujet: Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.
Alias Symbols: APAA, UCE
Protein Interaction Partner: ZHX2, DEGS1, NAGPA, EPS15, AP2A1, FURIN,
Protein Size: 515

Poids moléculaire: 53 kDa

ID gène: 51172

NCBI Accession: NM_016256, NP_057340

UniProt: Q9UK23