GP6 anticorps (Middle Region)

N° du produit ABIN2782886

Détail du produit anti-GP6 anticorps

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GP6 est non-conjugé

Application: Western Blotting (WB)

Séquence: PPSPVAEFSE ATAELTVSFT NEVFTTETSR SITASPKESD SPAGPARQYY

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against GP6. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human GP6

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 339 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur GP6

Antigène: GP6 (Glycoprotein VI (Platelet) (GP6))

Autre désignation: GP6 (GP6 Produits)

Synonymes: anticorps BDPLT11, anticorps GPIV, anticorps GPVI, anticorps 9830166G18Rik, anticorps Gm469, anticorps Gpvi, anticorps GP6, anticorps glycoprotein VI platelet, anticorps glycoprotein 6 (platelet), anticorps glycoprotein VI, anticorps platelet glycoprotein VI, anticorps GP6, anticorps Gp6, anticorps LOC103346235

Sujet: Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Collagen receptor involved in collagen-induced platelet adhesion and activation. GP6 plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation and aggregation of platelets. Upon injury to the vessel wall and subsequent damage to the endothelial lining, exposure of the subendothelial matrix to blood flow results in deposition of platelets. Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. Platelet interaction with collagen occurs as a 2-step procedure: (1) the initial adhesion to collagen is followed by (2) an activation step leading to platelet secretion, recruitment of additional platelets, and aggregation. In physiologic conditions, the resulting platelet plug is the initial hemostatic event limiting blood loss. However, exposure of collagen after rupture of atherosclerotic plaques is a major stimulus of thrombus formation associated with myocardial infarction or stroke (Jandrot-Perrus et al., 2000 [PubMed 10961879]).[supplied by OMIM].
Alias Symbols: GPIV, GPVI, MGC138168, BDPLT11
Protein Interaction Partner: NCF1, TRAF4, TGFB1I1, LYN, PTK2B, CALM1, FCER1G, YES1, FCGR2A, FCGR3A, FYN, CRP,
Protein Size: 339

Poids moléculaire: 37 kDa

ID gène: 51206

NCBI Accession: NM_016363, NP_057447

UniProt: Q9HCN6