ATRX anticorps (C-Term)

N° du produit ABIN2783135

Cet anticorps anti-ATRX Polyclonal Lapin (ABIN2783135) détecte spécifiquement ATRX dans WB. L’anticorps est réactif avec des échantillons de Humain, Lapin, Porc et Chien.

Aperçu rapide pour ATRX anticorps (C-Term) (ABIN2783135)

Antigène: ATRX (helicase 2, X-linked (ATRX))

Reactivité: Humain, Lapin, Porc, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATRX est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ATRX anticorps

Épitope: C-Term

Fonction: ATRX Antibody - C-terminal region

Séquence: DQSDETSEDD KKQSKKGTEE KKKPSDFKKK VIKMEQQYES SSDGTEKLPE

Homologie: Dog: 88%, Human: 100%, Pig: 93%, Rabbit: 75%

Attributs du produit: This is a rabbit polyclonal antibody against ATRX. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human ATRX

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47775-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur ATRX

Antigène: ATRX (helicase 2, X-linked (ATRX))

Autre désignation: ATRX

Sujet:

Background Information: The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported.

Gene Name: similar to putative DNA dependent ATPase and helicase

Alternative Symbols: JMS, XH2, XNP, MRX52, RAD54, RAD54L, ZNF-HX

Protein Name: Transcriptional regulator ATRX

Poids moléculaire: 148kDa

ID gène: 546

UniProt: P46100