PLEKHO1 anticorps (N-Term)

N° du produit ABIN2783148

Cet anticorps Lapin Polyclonal détecte spécifiquement PLEKHO1 dans WB. Il présente une réactivité avec des échantillons de Humain, Rat, Boeuf (Vache) et Porc.

Aperçu rapide pour PLEKHO1 anticorps (N-Term) (ABIN2783148)

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Reactivité: Humain, Rat, Boeuf (Vache), Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PLEKHO1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-PLEKHO1 anticorps

Épitope: N-Term

Fonction: PLEKHO1 Antibody - N-terminal region

Séquence: MMKKNNSAKR GPQDGNQQPA PPEKVGWVRK FCGKGIFREI WKNRYVVLKG

Homologie: Cow: 86%, Human: 100%, Pig: 86%, Rat: 82%

Attributs du produit: This is a rabbit polyclonal antibody against PLEKHO1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human PLEKHO1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP47817-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Détails sur PLEKHO1

Antigène: PLEKHO1 (Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1))

Autre désignation: PLEKHO1

Sujet:

Background Information: PLEKHO1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP).PLEKHO1 may function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). PLEKHO1 appears to target ATM to the plasma membrane. PLEKHO1 appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. PLEKHO1 is also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Gene Name: Pleckstrin homology domain containing, family O member 1

Alternative Symbols: JBP, CKIP1, OC120, CKIP-1

Protein Name: Pleckstrin homology domain-containing family O member 1

Poids moléculaire: 46kDa

ID gène: 51177

NCBI Accession: NP_057358

UniProt: Q53GL0