REC8 anticorps (N-Term)

N° du produit ABIN2783199

Détail du produit anti-REC8 anticorps

Antigène: REC8 (REC8 Homolog (Yeast) (REC8))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Cheval, Boeuf (Vache), Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp REC8 est non-conjugé

Application: Western Blotting (WB)

Séquence: QLQIGVIRVY SQQCQYLVED IQHILERLHR AQLQIRIDME TELPSLLLPN

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against REC8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human REC8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 547 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur REC8

Antigène: REC8 (REC8 Homolog (Yeast) (REC8))

Autre désignation: REC8 (REC8 Produits)

Synonymes: anticorps Rec8L1, anticorps mrec, anticorps HR21spB, anticorps REC8L1, anticorps Rec8p, anticorps REC8 meiotic recombination protein, anticorps REC8 homolog (yeast), anticorps REC8, anticorps Rec8

Sujet: REC8 is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.This gene encodes a member of the kleisin family of SMC (structural maintenance of chromosome) protein partners. The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. In the mouse, the homologous protein is a key component of the meiotic cohesion complex, which regulates sister chromatid cohesion and recombination between homologous chromosomes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.
Alias Symbols: HR21spB, MGC950, REC8L1, Rec8p
Protein Interaction Partner: SYCP3, SMC3, SMC1A,
Protein Size: 547

Poids moléculaire: 62 kDa

ID gène: 9985

NCBI Accession: NM_005132, NP_005123

UniProt: O95072