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STING/TMEM173 anticorps (Middle Region)

TMEM173 Reactivité: Humain, Porc WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2783202
  • Antigène Voir toutes STING/TMEM173 (TMEM173) Anticorps
    STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
    Épitope
    • 19
    • 15
    • 12
    • 8
    • 7
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reactivité
    • 70
    • 25
    • 23
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Porc
    Hôte
    • 84
    • 5
    Lapin
    Clonalité
    • 73
    • 16
    Polyclonal
    Conjugué
    • 41
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp STING/TMEM173 est non-conjugé
    Application
    • 53
    • 32
    • 24
    • 22
    • 13
    • 13
    • 12
    • 9
    • 7
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    DPNIRFLDKL PQQTGDHAGI KDRVYSNSIY ELLENGQRAG TCVLEYATPL
    Homologie
    Human: 100%, Pig: 83%
    Attributs du produit
    This is a rabbit polyclonal antibody against TMEM173. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the middle region of human TMEM173
    Top Product
    Discover our top product TMEM173 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 379 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Panchanathan, Liu, Xin, Choubey: "Identification of a negative feedback loop between cyclic di-GMP-induced levels of IFI16 and p202 cytosolic DNA sensors and STING." dans: Innate immunity, Vol. 20, Issue 7, pp. 751-9, (2014) (PubMed).

    Duan, Ponomareva, Veeranki, Panchanathan, Dickerson, Choubey: "Differential roles for the interferon-inducible IFI16 and AIM2 innate immune sensors for cytosolic DNA in cellular senescence of human fibroblasts." dans: Molecular cancer research : MCR, Vol. 9, Issue 5, pp. 589-602, (2011) (PubMed).

    Gerhard, Wagner, Feingold, Shenmen, Grouse, Schuler, Klein, Old, Rasooly, Good, Guyer, Peck, Derge, Lipman, Collins, Jang, Sherry, Feolo, Misquitta, Lee, Rotmistrovsky, Greenhut, Schaefer, Buetow et al.: "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). ..." dans: Genome research, Vol. 14, Issue 10B, pp. 2121-7, (2004) (PubMed).

  • Antigène
    STING/TMEM173 (TMEM173) (Transmembrane Protein 173 (TMEM173))
    Autre désignation
    TMEM173 (TMEM173 Produits)
    Synonymes
    anticorps ERIS, anticorps MITA, anticorps MPYS, anticorps NET23, anticorps STING, anticorps 2610307O08Rik, anticorps Mita, anticorps RGD1562552, anticorps transmembrane protein 173, anticorps TMEM173, anticorps Tmem173
    Sujet
    TMEM173 acts as a facilitator of innate immune signaling. It is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon (IFN-alpha and IFN-beta) and exert a potent anti-viral state following expression. TMEM173 may be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons.It also may be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). TMEM173 mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
    Alias Symbols: FLJ38577, ERIS, MITA, MPYS, NET23, STING
    Protein Interaction Partner: MAVS, TBK1, UBC, TRAF3, IRF3, TOMM70A, TSPAN6, TRIM32, STT3B, TMEM259, YIPF5, HM13, CLPTM1L, MBOAT7, CCDC47, SEC61A1, CNNM3, LTN1, SLC39A14, GLMN, SGPL1, SURF4, RNF5, ABCC1, STT3A, IRAK1, ACSL3, DDOST, NPC1, TMEM173, TRIM56,
    Protein Size: 379
    Poids moléculaire
    42 kDa
    ID gène
    340061
    NCBI Accession
    NM_198282, NP_938023
    UniProt
    Q86WV6
    Pathways
    Activation of Innate immune Response
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