BAG3 anticorps (Middle Region)

N° du produit ABIN2783302

Détail du produit anti-BAG3 anticorps

Antigène: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Lapin, Cheval, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp BAG3 est non-conjugé

Application: Western Blotting (WB)

Séquence: NVTRPAAQPS FHQAQKTHYP AQQGEYQTHQ PVYHKIQGDD WEPRPLRAAS

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against BAG3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human BAG3

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 575 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur BAG3

Antigène: BAG3 (BCL2-Associated Athanogene 3 (BAG3))

Autre désignation: BAG3 (BAG3 Produits)

Synonymes: anticorps bag3-A, anticorps MGC53113, anticorps zgc:100859, anticorps BAG3, anticorps ATBAG3, anticorps BCL-2-associated athanogene 3, anticorps T28J14.160, anticorps T28J14_160, anticorps BAG-3, anticorps BIS, anticorps CAIR-1, anticorps MFM6, anticorps AA407278, anticorps Bis, anticorps mg638, anticorps BCL2 associated athanogene 3 L homeolog, anticorps BCL2-associated athanogene 3, anticorps BCL2 associated athanogene 3, anticorps BCL-2-associated athanogene 3, anticorps Bcl2-associated athanogene 3, anticorps bag3.L, anticorps bag3, anticorps BAG3, anticorps Bag3

Sujet: BAG3 inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. BAG3 has anti-apoptotic activity.BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: BAG-3, BIS, CAIR-1, MGC104307
Protein Interaction Partner: SF3B4, DAZAP2, ARRDC3, LITAF, MAGED1, PDE9A, HSPA8, PHLDB1, HSPB1, HSF1, STUB1, DNAJB6, AMOT, PDLIM7, MLF2, HSPB8, WBP2, UBC, MCM7, HSP90AB1, ETFA, MVP, ACLY, PSAP, PSME1, PSMD12, PSMD9, PSMD8, PSMD5, PSMD3, PSMD2, PSMC5, PSMC3, PSMC2, PSMC1, PSMB5, PSMB4
Protein Size: 575

Poids moléculaire: 61 kDa

ID gène: 9531

NCBI Accession: NM_004281, NP_004272

UniProt: O95817