ALG2 anticorps (C-Term)

N° du produit ABIN2783587

Cité dans 2 publications. Cet anticorps anti-ALG2 Polyclonal Lapin (ABIN2783587) détecte spécifiquement ALG2 dans WB. L’anticorps est réactif avec des échantillons de Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Chévre et Poisson zèbre (Danio rerio).

Aperçu rapide pour ALG2 anticorps (C-Term) (ABIN2783587)

Antigène: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Saccharomyces cerevisiae, Chévre, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ALG2 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ALG2 anticorps

Épitope: C-Term

Fonction: ALG2 Antibody - C-terminal region

Séquence: QSDLGQYVTF LRSFSDKQKI SLLHSCTCVL YTPSNEHFGI VPLEAMYMQC

Homologie: Cow: 100%, Dog: 93%, Goat: 86%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ALG2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human ALG2

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP48974-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ALG2 (ABIN2783587)

Cossins, Belaya, Hicks, Salih, Finlayson, Carboni, Liu, Maxwell, Zoltowska, Farsani, Laval, Seidhamed, Donnelly, Bentley, McGowan, Müller, Palace, Lochmüller, Beeson: "Congenital myasthenic syndromes due to mutations in ALG2 and ALG14." dans: Brain : a journal of neurology, Vol. 136, Issue Pt 3, pp. 944-56, (2013) (PubMed).

Rind, Schmeiser, Thiel, Absmanner, Lübbehusen, Hocks, Apeshiotis, Wilichowski, Lehle, Körner: "A severe human metabolic disease caused by deficiency of the endoplasmatic mannosyltransferase hALG11 leads to congenital disorder of glycosylation-Ip." dans: Human molecular genetics, Vol. 19, Issue 8, pp. 1413-24, (2010) (PubMed).

Détails sur ALG2

Antigène: ALG2 (Asparagine-Linked Glycosylation 2, alpha-1,3-Mannosyltransferase Homolog (ALG2))

Autre désignation: ALG2

Sujet:

Background Information: ALG2 is a member of the glycosyltransferase 1 family. It acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii).This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Gene Name: Asparagine-linked glycosylation 2, alpha-1,3-mannosyltransferase homolog (S. cerevisiae)

Alternative Symbols: CDG1I, CDGIi, CMS14, NET38, CMSTA3, hALPG2

Protein Name: Alpha-1,3/1,6-mannosyltransferase ALG2

Poids moléculaire: 47kDa

ID gène: 85365

NCBI Accession: NP_149078

UniProt: Q9H553