MAP4K4 anticorps (N-Term)

N° du produit ABIN2783612

Cet anticorps Lapin Polyclonal détecte spécifiquement MAP4K4 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache) et Poisson zèbre (Danio rerio).

Aperçu rapide pour MAP4K4 anticorps (N-Term) (ABIN2783612)

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAP4K4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-MAP4K4 anticorps

Épitope: N-Term

Séquence: PFIRDQPNER QVRIQLKDHI DRTRKKRGEK DETEYEYSGS EEEEEEVPEQ

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MAP4K4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MAP4K4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1166 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MAP4K4

Antigène: MAP4K4 (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4))

Autre désignation: MAP4K4

Sujet: MAP4K4 is the serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. MAP4K4 appears to act upstream of the JUN N-terminal pathway.The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: FLH21957, FLJ10410, FLJ20373, FLJ90111, HGK, KIAA0687, NIK, MEKKK4
Protein Interaction Partner: UBC, MOB1B, NME7, PPP1CC, HSP90AA1, PAXIP1, GRK5, TRAPPC9, PPP1CA, KIF26B, HIST2H2BE, SLC9A1, PRKCE, KIF5A, ZRANB1, DOK1, MAP3K7, NCK1, GBP3, RAP2A, RASA1, ITGB1, MAP3K1, BRCA1, ATL1,
Protein Size: 1239

Poids moléculaire: 142 kDa

ID gène: 9448

NCBI Accession: NM_004834, NP_004825

UniProt: O95819